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Roles of intestinal Parabacteroides in human health and diseases

Yanlong Cui1, Leshan Zhang1, Xin Wang1

  • 1Lab of Bioresources, College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, 712100, Shaanxi Province, China.

FEMS Microbiology Letters
|August 9, 2022
PubMed

Insights

Parabacteroides, a key gut bacteria, impacts host health, influencing diseases like obesity and IBD. Certain species show promise as probiotics for inflammation and gut homeostasis.

Area of Science:

  • Microbiology
  • Human Gut Microbiota
  • Host-Microbe Interactions

Background:

  • Parabacteroides spp. are core human gut bacteria, crucial for host health.
  • These bacteria are linked to metabolic syndrome, inflammatory bowel disease, and obesity.
  • They possess carbohydrate metabolism and short-chain fatty acid production capabilities.

Purpose of the Study:

  • To review the role of Parabacteroides spp. in host health and disease.
  • To focus on specific species: Parabacteroides distasonis, P. goldsteinii, P. johnsonii, and P. merdae.
  • To explore their therapeutic potential in maintaining gut homeostasis.

Main Methods:

  • Literature review focusing on Parabacteroides spp. and their association with host health.
  • Analysis of studies on the physiological characteristics of Parabacteroides.
  • Examination of research on antimicrobial resistance within Parabacteroides.

Main Results:

  • Parabacteroides spp. are associated with various host diseases, including metabolic syndrome, IBD, and obesity.
  • Antimicrobial resistance in Parabacteroides to antibiotics like clindamycin is a significant consideration.
  • Parabacteroides distasonis and P. goldsteinii demonstrate protective effects against inflammation and obesity in murine models.

Conclusions:

  • Parabacteroides spp. play a multifaceted role in host health and disease.
  • P. distasonis and P. goldsteinii are potential candidates for next-generation probiotics.
  • Further research into Parabacteroides spp. may lead to novel therapeutic strategies for gut health.
Keywords:
Parabacteroidesdiseasegut microbiotamechanism

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