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Delay-related activity in marmoset prefrontal cortex.

Raymond K Wong1,2, Janahan Selvanayagam1,2, Kevin D Johnston1,2,3

  • 1Graduate Program in Neuroscience, Western University, London, ON N6A 3K7, Canada.

Cerebral Cortex (New York, N.Y. : 1991)
|August 10, 2022
PubMed
Summary

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Marmoset prefrontal cortex (PFC) neurons show persistent activity during working memory (WM) tasks, similar to macaques. This validates the marmoset as a model for studying WM microcircuitry.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • Persistent delay-period activity in the prefrontal cortex (PFC) is a key neural signature of working memory (WM).
  • Investigating PFC microcircuitry in macaques is limited by anatomical constraints.
  • The common marmoset offers a lissencephalic alternative for studying PFC function.

Purpose of the Study:

  • To determine if marmoset PFC neurons exhibit persistent activity during WM tasks.
  • To validate the marmoset as an animal model for WM research.

Main Methods:

  • Wireless electrophysiological recordings in marmoset PFC.
  • Marmosets performed a delayed-match-to-location task on a touchscreen system.

Main Results:

  • Marmoset PFC neurons displayed sample-, delay-, and response-related activity, tuned to stimuli and linked to task performance.
Keywords:
delayed-response taskelectrophysiologypersistent firingprimateworking memory

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  • Population activity models accurately predicted stimulus location during the delay period.
  • Delay activity in marmoset PFC suggests stable mnemonic representations.

    • Conclusions:

    • Marmoset PFC neurons exhibit persistent delay activity, mirroring findings in macaques.
    • Common neural mechanisms for WM exist in macaque and marmoset PFC.
    • The marmoset is a suitable model for investigating WM microcircuitry.