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Updated: Sep 2, 2025
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
278
Adipose-Renal Axis in Diabetic Nephropathy
Ming Yang1,2, Panai Song2, Li Zhao3
1Department of Nutrition, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Current Medicinal Chemistry
|August 10, 2022
Summary
Diabetic nephropathy (DN) is a kidney disease caused by diabetes. Adipose tissue and its secreted adipokines play a role in DN progression, suggesting the "adipose-renal axis" as a potential therapeutic target.
Area of Science:
- Endocrinology
- Nephrology
- Metabolic Research
Background:
- Diabetic nephropathy (DN) is a significant complication of long-term diabetes, leading to end-stage renal disease (ESRD).
- The precise mechanisms underlying DN pathogenesis remain incompletely understood.
- Adipose tissue functions not only in energy storage but also as an endocrine organ, secreting various adipokines.
Purpose of the Study:
- To review and summarize identified adipokines.
- To emphasize the role of specific adipokines in the progression of diabetic nephropathy.
- To propose the "adipose-renal axis" as a potential therapeutic strategy for DN.
Main Methods:
- Literature review and synthesis of existing research on adipokines and diabetic nephropathy.
- Analysis of studies investigating the endocrine functions of adipose tissue.
- Identification and discussion of key adipokines implicated in renal injury.
Main Results:
- Adipokines secreted by adipose tissue influence metabolic homeostasis.
- Specific adipokines have been identified as contributors to the progression of diabetic nephropathy.
- The interplay between adipose tissue and the kidneys, termed the "adipose-renal axis," is increasingly recognized.
Conclusions:
- Adipokines play a crucial role in the development and progression of diabetic nephropathy.
- The "adipose-renal axis" represents a novel and promising target for the development of treatments for DN.
- Further research into adipokine function could lead to innovative therapeutic interventions for diabetic kidney disease.
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