Clinical-experimental research on aztreonam ampullar and ureteral concentrations

After pointing out that, during urinary tract infections, bacteria can affect the peristalsis of the renal ampulla and of the ureter, the authors report the results of a trial on aztreonam concentrations in the upper urinary tract, performed in order to evaluate the concentrations of the drug in the ampullar and ureteral tissues. This study was carried out on bioptical specimens collected from 18 subjects (12 children and 6 adults), who underwent surgery for malformations of the urinary system. The authors report and discuss the results of the determinations performed on the samples of urinary tract tissue, serum and urine, 60 to 90 minutes after the i.m. administration of aztreonam.