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Role of ROS‑mediated autophagy in melanoma (Review)

Xuebing Zhang1, Huaijun Li1, Chengxiang Liu1

  • 1Department of Dermatology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China.

Molecular Medicine Reports
|August 10, 2022
PubMed

Insights

Reactive oxygen species (ROS) and autophagy influence melanoma development and drug resistance. Understanding their interaction clarifies melanoma pathogenesis and suggests new therapeutic strategies.

Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Melanoma, an aggressive skin cancer, has a poorly understood pathogenesis.
  • Reactive oxygen species (ROS) and autophagy are critical regulators of cellular homeostasis implicated in melanoma.
  • The interplay between ROS and autophagy in melanoma etiology and treatment remains unclear.

Purpose of the Study:

  • To review the role of ROS and oxidative stress in melanoma.
  • To summarize the function of ROS-mediated autophagy in melanomagenesis.
  • To elucidate the impact of ROS-autophagy interaction on melanoma cell fate after anticancer drug treatment.

Main Methods:

  • Literature review on ROS production and oxidative stress in melanoma.
  • Analysis of studies investigating ROS-mediated autophagy in melanoma.
  • Synthesis of findings on melanoma progression and drug resistance.

Main Results:

  • Oxidative stress and ROS play a significant role in melanoma development.
  • ROS-mediated autophagy influences melanomagenesis and melanoma cell fate.
  • The interaction impacts melanoma progression and response to therapy.

Conclusions:

  • Clarifying the ROS-autophagy axis enhances understanding of melanoma pathogenesis.
  • Targeting ROS-mediated autophagy may offer novel therapeutic avenues for melanoma treatment.
Keywords:
autophagymelanomamelanomagenesisoxidative stressreactive oxygen species

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