Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

913
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
913
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

179
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
179
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

133
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
133
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

149
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
149
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

162
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
162
Personality Disorders: Schizotypal and Histrionic01:20

Personality Disorders: Schizotypal and Histrionic

160
Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...
160

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reconsidering the Term "Treatment Resistant Schizophrenia".

Schizophrenia bulletin·2026
Same author

Comparing saliva collection and DNA extraction methods for saliva-based microbiome profiling.

Frontiers in microbiology·2026
Same author

Blockade of Tim-3 pathway in a mouse model of Toxoplasmosis: impact on brain leukocyte infiltration, parasite burden, and neuroinflammation.

Scientific reports·2026
Same author

Uneven Recovery: Intersectional Disparities in Youth Mental Health After COVID-19.

Academic pediatrics·2026
Same author

Cytomegalovirus-encoded immediate early 1 protein perturbs neural progenitor proliferation via interfering with host PML-DISC1 interaction.

The Journal of biological chemistry·2026
Same author

An overview of risk factors for clinical toxoplasmosis.

Parasitology·2026

Related Experiment Video

Updated: Sep 2, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.8K

Non-SARS Coronaviruses in Individuals with Psychiatric Disorders.

Faith B Dickerson1, Emily G Severance2, Robert H Yolken2

  • 1Stanley Research Program, Sheppard Pratt, Baltimore, MD, USA. fdickerson@sheppardpratt.org.

Current Topics in Behavioral Neurosciences
|August 10, 2022
PubMed
Summary
This summary is machine-generated.

Individuals with schizophrenia showed higher antibody levels to seasonal Coronaviruses OC43 and NL63, suggesting a potential link between these viruses and schizophrenia. Further research is needed to explore this association.

Keywords:
AntibodiesCoronavirusInfectionPandemicPsychiatric disordersSchizophrenia

More Related Videos

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
06:15

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

Published on: July 15, 2025

408
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

1.3K

Related Experiment Videos

Last Updated: Sep 2, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.8K
A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
06:15

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

Published on: July 15, 2025

408
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

1.3K

Area of Science:

  • Neuroscience
  • Immunology
  • Virology

Background:

  • Coronaviruses are significant to human health, with seasonal strains endemic globally.
  • Previous research indicated elevated antibodies to seasonal coronaviruses in individuals with recent-onset psychosis.
  • This study investigated antibody levels to seasonal coronaviruses in psychiatric disorder patients versus a control group.

Purpose of the Study:

  • To compare seasonal coronavirus antibody levels between individuals with psychiatric disorders and a non-psychiatric comparison group.
  • To explore potential associations between specific seasonal coronaviruses and psychiatric conditions.

Main Methods:

  • 195 participants with schizophrenia, bipolar disorder, major depressive disorder, or no psychiatric disorder were included.
  • IgG antibodies to spike proteins of four non-SARS coronaviruses (229E, HKU1, NL63, OC43) were measured.
  • Linear and logistic regression models analyzed antibody levels and odds ratios, adjusting for demographics.

Main Results:

  • The schizophrenia group exhibited significantly higher antibody levels to OC43 and NL63.
  • Increased odds of elevated OC43 antibodies were observed in the schizophrenia group.
  • The major depression group showed lower antibodies to 229E; no significant differences for 229E or HKU1 in other groups.

Conclusions:

  • Elevated OC43 and NL63 antibodies in schizophrenia suggest increased exposure and a potential role in the disorder's etiopathology.
  • The causal relationship between seasonal coronaviruses and psychiatric disorders warrants further investigation.
  • Longitudinal cohort studies are recommended to clarify the cause-and-effect relationship.