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Related Experiment Video

Updated: Sep 2, 2025

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Protein-based polymer liquid embolics for cerebral aneurysms.

Mark M Jensen1, Øyvind Hatlevik2, D Douglas Steinhauff1

  • 1Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA.

Acta Biomaterialia
|August 10, 2022
PubMed
Summary
This summary is machine-generated.

A novel silk-elastinlike protein polymer (SELP) effectively treated cerebral aneurysms in a rabbit model. This promising embolic therapy achieved high occlusion rates without adverse effects, showing potential for unruptured cerebral aneurysm treatment.

Keywords:
Cerebral aneurysmEmbolizationProtein-based polymerRabbit elastase modelRecombinant protein

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Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Regenerative Medicine

Background:

  • Cerebral aneurysms (CA) pose a significant risk of rupture, leading to hemorrhagic stroke.
  • Current treatments like clipping and endovascular coiling have limitations, including safety concerns and device migration.
  • There is a need for advanced embolic therapies that promote healing and reduce CA risks.

Purpose of the Study:

  • To evaluate the efficacy and safety of a bioinspired silk-elastinlike protein-based polymer (SELP 815K) as a liquid embolic agent for cerebral aneurysms.
  • To assess the potential of SELP 815K to promote aneurysm healing and reendothelialization.

Main Methods:

  • SELP 815K was used to embolize experimental aneurysms in a rabbit elastase model.
  • Occlusion rates, device-associated adverse effects, and cytotoxicity were evaluated.
  • Histological examination was performed one month post-embolization to assess tissue response and healing.

Main Results:

  • SELP 815K achieved over 90% occlusion of model aneurysms in vivo using standard microcatheters.
  • No device-related adverse effects or cytotoxicity were observed.
  • Histological analysis revealed features consistent with reendothelialization of the aneurysm neck without local tissue damage.

Conclusions:

  • SELP 815K demonstrates significant promise as a safe and effective liquid embolic agent for treating unruptured cerebral aneurysms.
  • The material's ability to gel at body temperature and promote healing offers a potential advancement over existing therapies.
  • SELP embolization provides a platform for delivering bioactive agents to further enhance aneurysm repair.