Related Experiment Video
Updated: Sep 2, 2025
03:32
Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
Published on: December 27, 2024
902
Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective
Haruhisa Suzuki1, Hiroyuki Ono2, Toshiaki Hirasawa3
1Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Summary
Endoscopic resection (ER) is effective for early gastric cancers (EGCs) across multiple pathological categories. This study confirms ER
Area of Science:
- Gastroenterology
- Oncology
- Surgical Endoscopy
Background:
- Early gastric cancer (EGC) management requires understanding long-term outcomes.
- Endoscopic resection (ER) is a minimally invasive option for EGC.
- Pathological curability impacts treatment effectiveness.
Purpose of the Study:
- To clarify long-term outcomes of ER for EGCs.
- To evaluate ER effectiveness based on pathological curability.
- To compare ER outcomes with surgical resection benchmarks.
Main Methods:
- Multicenter prospective cohort study of 9054 patients with 10,021 EGCs undergoing ER.
- Primary endpoint: 5-year overall survival (OS).
- Pathological curability categorized (A1-C) based on tumor type, size, ulceration, invasion depth, and resection margins.
Main Results:
- The 5-year OS for all EGCs treated with ER was 89.0%.
- No significant difference in mortality hazard ratios between Category A1 and Categories A2, A3, or B.
- ER met the effectiveness threshold for all pathological curability categories analyzed.
Conclusions:
- Endoscopic resection is recommended for EGCs meeting criteria for Categories A1, A2, A3, and B.
- ER offers effective long-term outcomes comparable to surgery for specific EGC subtypes.
- This study supports ER as a standard treatment for eligible EGC patients.
