Related Experiment Video
Updated: Sep 2, 2025
Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
Published on: July 17, 2018
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives
1School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Abstract:
Drug discovery for obesity treatment, particularly bodily slimming, is a topic of timely importance that requires continued investigation, as the current therapies have limited efficacy with many adverse effects. Obesity is associated with adipose tissue expansion, where the size and number of adipocytes increase. Over the past few decades, high-throughput/content screening (HTS/HCS) has been carried out on morphological changes in adipose tissues and adipocytes for the development of anti-obesity therapies. Increased understating of current adipocyte-based HTS/HCS technology will facilitate drug screening for obesity and weight control.
Insights
Investigating new obesity treatments is crucial due to limited efficacy and side effects of current therapies. Understanding adipocyte-based high-throughput screening (HTS/HCS) aids in developing effective anti-obesity drugs for weight control.
Area of Science:
- Pharmacology and Cell Biology
- Focuses on drug discovery and cellular mechanisms related to obesity.
Background:
- Obesity is a growing health concern linked to adipose tissue expansion and increased adipocyte size/number.
- Current obesity therapies offer limited efficacy and significant adverse effects, necessitating novel treatment strategies.
Purpose of the Study:
- To highlight the importance of continued investigation into drug discovery for obesity treatment.
- To emphasize the role of adipocyte-based high-throughput/content screening (HTS/HCS) in developing anti-obesity therapies.
Main Methods:
- Review of existing research on adipocyte-based high-throughput/content screening (HTS/HCS) technologies.
- Analysis of morphological changes in adipose tissues and adipocytes as screening targets.
Main Results:
- High-throughput/content screening (HTS/HCS) has been utilized for decades in developing anti-obesity drugs.
- Morphological changes in adipocytes are key indicators for drug screening.
Conclusions:
- Enhanced understanding of adipocyte-based HTS/HCS technology is vital for advancing drug discovery in obesity and weight management.
- Further research in this area promises to improve the efficacy and safety of anti-obesity treatments.
