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Improving interferon-γ release assay interpretation: are IP-10 and MIG the solution?

Francesca Saluzzo1,2, Claudia M Denkinger3,4, Daniela M Cirillo5

  • 1IRCCS San Raffaele Scientific Institute, Milan, Italy.

The European Respiratory Journal
|August 10, 2022
PubMed
Summary

No abstract available in PubMed .

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

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