Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

3.9K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.9K
Metastasis02:30

Metastasis

5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
Negative Regulator Molecules01:23

Negative Regulator Molecules

35.8K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fragility of precision: resistance to mutant p53 reactivation.

Signal transduction and targeted therapy·2026
Same author

Spatial proteomics profiling reveals oncogene-specific immune niches and prognostic markers in NSCLC.

American journal of respiratory and critical care medicine·2026
Same author

From Cellular Radiosensitivity to Precision Radiotherapy: Integrating Functional Assays, Genomics, and Clinical Modeling.

Cancers·2026
Same author

IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition.

Cell metabolism·2026
Same author

Tumor microenvironment evolution in lung cancer: Spatio-temporal dynamics and clinical implications.

Seminars in cancer biology·2026
Same author

DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Sep 2, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

9.6K

p73 isoforms meet evolution of metastasis.

Stella Logotheti1, Athanasia Pavlopoulou2,3, Stephan Marquardt4

  • 1DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), 15780, Zografou, Greece. stella_logotheti@mail.ntua.gr.

Cancer Metastasis Reviews
|August 10, 2022
PubMed
Summary

The TP73 gene, a relative of TP53, plays a complex role in cancer evolution and metastasis. Its diverse isoforms collaborate under selective pressures, aiding tumor cells in overcoming metastatic barriers and driving cancer progression.

Keywords:
Cancer evolutionCo-optionDevelopmental and tissue homeostasis programsMetastasisTumor evolutionary trajectoriesp73 isoforms

More Related Videos

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.6K
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.5K

Related Experiment Videos

Last Updated: Sep 2, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

9.6K
Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.6K
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.5K

Area of Science:

  • Evolutionary biology
  • Molecular oncology
  • Genetics

Background:

  • Cancer progression often follows Darwinian selection principles, with metastasis being a critical, therapy-resistant stage.
  • Tumors adapt by co-opting developmental programs, and therapy introduces additional selective pressures.
  • The TP73 gene, a homolog of TP53, is known to regulate development and tissue homeostasis, with implications in cancer.

Purpose of the Study:

  • To review the role of the TP73 gene and its isoforms in cancer evolution, particularly during metastasis.
  • To explore how TP73's diverse isoforms contribute to tumor adaptation and progression under selective pressures.
  • To investigate the potential of targeting TP73 isoforms for cancer metastasis prevention and therapy.

Main Methods:

  • Review of existing literature on TP73 function in cancer evolution.
  • Analysis of TP73's role in embryonic development, tissue homeostasis, and cancer.
  • Examination of isoform-specific functions and their combinatorial effects in cancer cells.

Main Results:

  • TP73 exhibits complex, non-binary effects, with antagonistic and cooperative functions among its isoforms.
  • Co-expressed TP73 isoforms can activate distinct programs, conferring selective advantages for metastasis.
  • TP73's pleiotropic functions support clonal expansion and tumor evolution, especially in dynamic microenvironments.

Conclusions:

  • TP73 isoforms do not simply mimic TP53 but orchestrate complex evolutionary strategies within cancer cells.
  • Understanding TP73 isoform patterns across tumor evolution is crucial for developing targeted anti-metastasis therapies.
  • Targeting specific TP73 isoform activities may offer novel strategies for cancer metastasis prevention and treatment.