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Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report
Joon Hyun Cho1, Jun Hyeon Byeon1, Si Hyung Lee2
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu 42415, South Korea.
World Journal of Gastroenterology
|August 11, 2022
Summary
This case study presents the first endoscopic resection and follow-up of a small gastric dedifferentiated liposarcoma (DL). The successful endoscopic removal highlights its potential for diagnosing uncertain gastric submucosal tumors.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Liposarcoma, a common mesenchymal tumor, is rare in the stomach, with well-differentiated or myxoid subtypes most frequently reported.
- Small gastric liposarcomas requiring endoscopic resection and follow-up are exceptionally uncommon in medical literature.
Observation:
- A 67-year-old female presented with a gastric submucosal tumor (SMT) measuring 17 mm × 10 mm.
- Endoscopic ultrasound and CT scans characterized the mass, with CT showing no distant metastasis.
- Endoscopic resection using snare technique confirmed dedifferentiated liposarcoma (DL) with positive deep resection margins.
Findings:
- Immunohistochemistry confirmed DL through MDM2 and CDK4 expression.
- Despite positive margins, the patient declined further surgery or adjuvant therapy.
- One-year follow-up revealed no disease recurrence after endoscopic resection.
Implications:
- This case is the first report of a small primary gastric DL successfully resected endoscopically with follow-up.
- Endoscopic resection is a viable option for diagnosing uncertain gastric SMTs.
- This approach may offer a less invasive alternative for managing specific gastric tumors.
