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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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The Functions of the Skeletal System01:22

The Functions of the Skeletal System

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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Use of Human Perivascular Stem Cells for Bone Regeneration
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Published on: May 25, 2012

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Adipose tissue in bone regeneration - stem cell source and beyond.

Luminita Labusca1

  • 1Magnetic Materials and Sensors, National Institute of Research and Development for Technical Physics, Iasi 700050, Romania.

World Journal of Stem Cells
|August 11, 2022
PubMed
Summary
This summary is machine-generated.

Adipose tissue (AT) plays vital roles in body homeostasis and regeneration. AT-derived stem cells show promise for bone healing and regenerative medicine, though clinical translation faces challenges.

Keywords:
Adipose tissueAdipose-derived stem cellsBone engineeringBone metabolismDedifferentiated fat cellsFracture healingMultilineage differentiating stress-enduring

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Area of Science:

  • Adipose tissue biology and regenerative medicine.

Background:

  • Adipose tissue (AT) is a complex organ regulating homeostasis, immunity, and reproduction.
  • Its role in tissue repair and regeneration is increasingly recognized.
  • Different AT compartments and their link to bone metabolism are key areas of study.

Purpose of the Study:

  • To present different adipose tissue compartments and their interrelation with bone metabolism.
  • To describe adipose-derived stem cell populations and their potential in bone regeneration.
  • To review current applications and challenges of AT-derived stem cells in fracture healing and bone regeneration.

Main Methods:

  • Review of adipose tissue compartments (white, brown, bone marrow AT).
  • Characterization of adipose-derived stem cell populations (mesenchymal, pluripotent-like, dedifferentiated fat cells).
  • Analysis of cell therapy and tissue engineering strategies for bone repair.

Main Results:

  • Adipose tissue compartments are interconnected with bone metabolism.
  • Adipose-derived stem cells offer a readily available source for regenerative applications.
  • These cells show potential in bone and fracture healing strategies.

Conclusions:

  • Adipose tissue is a crucial organ for homeostasis and regeneration.
  • Adipose-derived stem cells are promising for bone regenerative medicine.
  • Further research is needed to overcome challenges in clinical translation for bone repair.