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Use of Human Perivascular Stem Cells for Bone Regeneration
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Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

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Adipose tissue in bone regeneration - stem cell source and beyond

Luminita Labusca1

  • 1Magnetic Materials and Sensors, National Institute of Research and Development for Technical Physics, Iasi 700050, Romania.

World Journal of Stem Cells
|August 11, 2022
PubMed

Adipose tissue (AT) is recognized as a complex organ involved in major home-ostatic body functions, such as food intake, energy balance, immunomodulation, development and growth, and functioning of the reproductive organs. The role of AT in tissue and organ homeostasis, repair and regeneration is increasingly recognized. Different AT compartments (white AT, brown AT and bone marrow AT) and their interrelation with bone metabolism will be presented. AT-derived stem cell populations - adipose-derived mesenchymal stem cells and pluripotent-like stem cells. Multilineage differentiating stress-enduring and dedifferentiated fat cells can be obtained in relatively high quantities compared to other sources. Their role in different strategies of bone and fracture healing tissue engineering and cell therapy will be described. The current use of AT- or AT-derived stem cell populations for fracture healing and bone regenerative strategies will be presented, as well as major challenges in furthering bone regenerative strategies to clinical settings.

Keywords:
Adipose tissueAdipose-derived stem cellsBone engineeringBone metabolismDedifferentiated fat cellsFracture healingMultilineage differentiating stress-enduring

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