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Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States
Wilfredo R Matias1, Jacob M Koshy2, Ellen H Nagami1
1Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Abstract:
A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox.
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