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Antimicrobial screening to molecular docking of newly synthesized ferrocenyl-substituted pyrazole
Shashi Sharma1, Hardeep Singh Tuli2, Mehmet Varol3
1Department of Chemistry, Dyal Singh College, Karnal, Haryana, India.
Objective:
Microbial diseases are snowballing at an alarming proportion. Therefore, the intent of this study was to inspect the antimicrobial action of ferrocenyl-substituted pyrazole against various human pathogenic Gram-positive, Gram-negative, and fungal microbial strains. Pyrazoles have been recognized for over a century as a significant and bioactive class of heterocyclic compounds. The association of pyrazoles with a ferrocene moiety may give new class of compounds. The present study was designed to synthesize biological active ferrocenyl-substituted pyrazole through a novel route.
Methods:
The anhydride of ferrocenyl-substituted pyrazole, namely, (S)-(3-(3-(carboxyamino)-3H-pyrazol-4-yl)cyclopenta-1,3-dien-1-yl)(cyclopenta-1,3-dien-1-yl)iron was synthesized using expansion cyclocondensation. FTIR, NMR, and GC-MS were performed to analyze the structure of the synthesized ferrocenyl-substituted pyrazole. Antimicrobial, DNA photo-cleaving, and anti-angiogenic activities of ferrocenyl-substituted compounds were studied.
Results:
Anhydride of (S)-(3-(3-(carboxyamino)-3H-pyrazol-4-yl)cyclopenta-1,3-dien-1-yl)(cyclopenta-1,3-dien-1-yl)iron obtained with yield of 87%. Spectral analysis confirmed the formation of anhydride. The synthesized compound was found to be biological active in the range of 85-95 μg/ml.
Conclusion:
This study described the novel method for the synthesis of biologically active anhydride of ferrocenyl-substituted pyrazole. The study demonstrations that synthesized ferrocenyl-substituted pyrazole in today's situation is the encouraging antimicrobial mediator against the human pathogens. In addition, it may open new doors to initiate research against drug resistance bacteria with possible biomedical applications.
Insights
A novel ferrocenyl-substituted pyrazole was synthesized and demonstrated significant antimicrobial activity against human pathogens. This discovery offers a promising new avenue for combating drug-resistant bacteria and potential biomedical applications.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Microbiology
Background:
- Microbial diseases are a growing global health concern.
- Pyrazoles are a well-established class of bioactive heterocyclic compounds.
- Ferrocene-containing compounds represent a novel area for drug discovery.
Purpose of the Study:
- To synthesize a novel ferrocenyl-substituted pyrazole derivative.
- To evaluate the antimicrobial potential of the synthesized compound against human pathogens.
- To explore potential biomedical applications of this new class of compounds.
Main Methods:
- Synthesis of ferrocenyl-substituted pyrazole anhydride via expansion cyclocondensation.
- Structural characterization using FTIR, NMR, and GC-MS.
- Assessment of antimicrobial activity against Gram-positive, Gram-negative, and fungal strains.
Main Results:
- The novel ferrocenyl-substituted pyrazole anhydride was synthesized with an 87% yield.
- Spectral analysis confirmed the compound's structure.
- The synthesized compound exhibited significant biological activity in the range of 85-95 μg/ml.
Conclusions:
- A novel synthetic route for biologically active ferrocenyl-substituted pyrazole was established.
- The synthesized compound shows promise as an antimicrobial agent against human pathogens.
- This research opens possibilities for developing new treatments for drug-resistant bacteria.
