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Paclitaxel-Induced Pneumonitis in Trinidad: A Case Report
Nishtha Mohan1, Dominic Dalip2,3, Fidel S Rampersad4
1Internal Medicine, The University of the West Indies, Saint Augustine, TTO.
Cureus
|August 11, 2022
Summary
Paclitaxel-induced pneumonitis (PIP) is a rare immune reaction to chemotherapy. This report details a case of PIP in Trinidad, highlighting its occurrence in a new geographic region.
Area of Science:
- Pulmonology
- Oncology
- Immunology
Background:
- Paclitaxel is a key chemotherapeutic agent for breast cancer.
- Paclitaxel-induced pneumonitis (PIP) is a delayed hypersensitivity (Type IV) immune response.
- PIP diagnosis relies on excluding other conditions due to lack of a specific test.
Observation:
- This report details a case of PIP in Trinidad, West Indies.
- This presentation marks the first documented instance of PIP in this region.
- PIP diagnosis involved laboratory work-up, imaging, biopsy, and antibiotic therapy response.
Findings:
- PIP presents as ground-glass opacities on CT scans.
- Pulmonary function tests (PFTs) show minimal restrictive disturbance and decreased diffusion.
- Bronchoalveolar lavage (BAL) and bronchoscopy cultures were negative.
Implications:
- Increased awareness of PIP in diverse geographic settings is crucial.
- Physicians should consider PIP in patients on paclitaxel with compatible respiratory symptoms.
- Early recognition and diagnosis of PIP can guide treatment adjustments.
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