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Mortality and Change in the Prevalence of Deep Vein Thrombosis Associated With SARS-CoV-2 P.1 Variant

Jose Maria Pereira de Godoy1,2, Gleison Juliano Da Silva Russeff3, Carolina Hungaro Cunha3

  • 1Cardiology and Cardiovascular Surgery, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, BRA.

Cureus
|August 11, 2022
PubMed

Insights

Deep vein thrombosis (DVT) incidence significantly increased in COVID-19 patients during the SARS-CoV-2 P.1 variant predominance. Early DVT diagnosis and reassessed prophylaxis are crucial for managing these patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Hematology

Background:

  • Thrombosis is a major challenge in cardiovascular diseases and a leading cause of mortality.
  • Coronavirus disease 2019 (COVID-19) has been associated with increased thrombotic events.
  • The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants may impact disease presentation and complications.

Purpose of the Study:

  • To determine mortality rates by sex and age in COVID-19 patients.
  • To assess the prevalence of deep vein thrombosis (DVT) in hospitalized COVID-19 patients.
  • To investigate the influence of the SARS-CoV-2 P.1 variant on DVT prevalence.

Main Methods:

  • Analysis of hospital data from 6,199 COVID-19 patients between March 2020 and June 2021.
  • Diagnosis of DVT using lower limb echo-Doppler ultrasound (EDU).
  • Comparison of DVT prevalence and mortality rates before and after the predominance of the SARS-CoV-2 P.1 variant.

Main Results:

  • Mortality rates were significantly higher in men (38.36%) than women (27.16%).
  • DVT incidence in COVID-19 patients rose from 1.6% to 7.7% during P.1 variant predominance (p=0.0001).
  • Mortality was significantly higher in COVID-19 patients with DVT (58.1%) compared to those without (33.6%; p=0.0001).

Conclusions:

  • The P.1 variant's predominance correlated with increased incidence and prevalence of DVT in COVID-19 patients.
  • Early diagnosis of DVT is essential for improving outcomes.
  • Reassessment of prophylactic strategies for DVT in COVID-19 patients is recommended.

Keywords:
deep vein thrombosismortalityprevalencevariantviral

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