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Updated: Sep 2, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.8K

A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the

Li Guo1, Sunjing Li1, Xiaoqiang Yan1

  • 1Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

Computational and Structural Biotechnology Journal
|August 11, 2022
PubMed

Insights

The Notch pathway is crucial in cancer development. Multi-omics analysis reveals its regulation by ncRNAs and potential as a prognostic marker for personalized cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • The Notch signaling pathway regulates fundamental cellular processes and is implicated in cancer.
  • Understanding its molecular mechanisms in cancer is vital for therapeutic advancements.

Purpose of the Study:

  • To conduct a comprehensive multi-omics analysis of the Notch pathway in cancer.
  • To explore its somatic mutation landscape, gene expression, ncRNA regulation, and prognostic value.

Main Methods:

  • Pan-cancer analysis of somatic mutations and gene expression for 22 core Notch genes.
  • Investigation of ncRNA:mRNA and competing endogenous RNA (ceRNA) networks.
  • Integration of multi-omics data to assess prognostic power and immune infiltration correlation.

Main Results:

  • Notch core genes exhibit relative stability in DNA variation.
  • Dynamic expression patterns linked to Notch activity are modulated by ncRNAs.
  • The Notch pathway demonstrates prognostic potential, correlates with immune infiltration, and suggests drug targets.

Conclusions:

  • The Notch pathway plays a critical role in cancer pathophysiology.
  • Insights into RNA crosstalk within the Notch pathway support its application in precision medicine.
  • Findings highlight the potential for individualized cancer treatment strategies targeting the Notch pathway.
Keywords:
Molecular featuresMulti-omicsNotch signaling pathwayPan-cancerPrognosisncRNA

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