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Diagnostic Value of DCE-MRI and Tofts Model in Children with Unilateral Hydronephrosis

Yiwei Yin1, Yi Zhou1, Siping He1

  • 1Department of Radiology, Hunan children's Hospital, No. 86, Ziyuan Road, Yuhua District, Changsha City, Hunan Province, China.

Current Medical Imaging
|August 11, 2022
PubMed

Insights

Dynamic contrast-enhanced MRI (DCE-MRI) with the Tofts model aids in diagnosing pediatric hydronephrosis. This method offers high sensitivity and specificity for evaluating renal morphology and function in affected children.

Area of Science:

  • Pediatric Radiology
  • Medical Imaging Analysis

Background:

  • Hydronephrosis is a common pediatric condition requiring accurate diagnosis for effective management.
  • Early detection of pediatric hydronephrosis is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the diagnostic utility of dynamic contrast-enhanced MRI (DCE-MRI) analyzed with the Tofts model in pediatric unilateral hydronephrosis.
  • To compare the pharmacokinetic parameters and renal function indexes between affected and healthy kidneys in children with hydronephrosis.

Main Methods:

  • Retrospective analysis of 88 children with unilateral hydronephrosis.
  • Collection of routine and DCE-MRI renal image indexes.
  • Calculation of pharmacokinetic variables using the Tofts model.
  • Comparison of kinetic parameters, parenchymal thickness, and ROC curves.

Main Results:

  • Diseased kidneys showed lower Ktrans, Kep, and Ve values compared to normal kidneys (P<0.05).
  • Renal parenchyma thickness was reduced in affected kidneys, particularly in severe cases.
  • DCE-MRI with the Tofts model demonstrated higher sensitivity (86.36%) and specificity (71.59%) than DCE-MRI alone, with an AUC of 0.789.

Conclusions:

  • DCE-MRI combined with the Tofts model effectively assesses renal morphology and function in pediatric hydronephrosis.
  • This integrated approach offers high sensitivity and specificity for diagnosing hydronephrosis in children.
  • The findings support the use of DCE-MRI and Tofts model for improved diagnosis of pediatric hydronephrosis.
Abstract

Keywords:
DCE-MRIdiagnostic valuehydronephrosis in childrenrenal functiontofts model

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