Related Experiment Video
Updated: Sep 2, 2025
05:03
Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
Published on: December 27, 2024
1.2K
Development and Challenges of Synthetic Retinoid Formulations in Cancer
Sara Assi1, Hiba El Hajj2, Berthe Hayar3
1Department of Biomedical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon.
Current Drug Delivery
|August 11, 2022
Summary
Retinoids, vitamin A derivatives, show anti-cancer potential but face delivery challenges. This review explores synthetic retinoids and advanced delivery systems to improve cancer treatment efficacy.
Area of Science:
- Biochemistry and Molecular Biology
- Pharmacology and Pharmaceutical Sciences
- Oncology
Background:
- Retinoids, vitamin A derivatives, are vital for biological processes like cell growth and differentiation.
- Retinoids demonstrate significant anti-cancer properties in preclinical models for various cancers.
- Clinical application of retinoids is hindered by poor solubility, photosensitivity, short half-life, and toxicity.
Conclusions:
- Synthetic retinoids hold promise as anti-cancer agents.
- Optimized delivery systems are crucial for successful clinical translation of retinoids.
- Further research into novel retinoid delivery strategies can enhance cancer treatment effectiveness.
More Related Videos
Related Concept Videos
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
02:49Cancer Therapies
7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
01:25Mutagenicity and Carcinogenicity
1.4K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.4K