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Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
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Development and Challenges of Synthetic Retinoid Formulations in Cancer

Sara Assi1, Hiba El Hajj2, Berthe Hayar3

  • 1Department of Biomedical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon.

Current Drug Delivery
|August 11, 2022
PubMed

Insights

Retinoids, vitamin A derivatives, show anti-cancer potential but face delivery challenges. This review explores synthetic retinoids and advanced delivery systems to improve cancer treatment efficacy.

Area of Science:

  • Biochemistry and Molecular Biology
  • Pharmacology and Pharmaceutical Sciences
  • Oncology

Background:

  • Retinoids, vitamin A derivatives, are vital for biological processes like cell growth and differentiation.
  • Retinoids demonstrate significant anti-cancer properties in preclinical models for various cancers.
  • Clinical application of retinoids is hindered by poor solubility, photosensitivity, short half-life, and toxicity.

Conclusions:

  • Synthetic retinoids hold promise as anti-cancer agents.
  • Optimized delivery systems are crucial for successful clinical translation of retinoids.
  • Further research into novel retinoid delivery strategies can enhance cancer treatment effectiveness.
Keywords:
Synthetic retinoidcancerdelivery systemdevelopmentdrugformulation

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