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Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
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Disorders of the Skeletal Muscle01:28

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Updated: Sep 1, 2025

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
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Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

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COVID-19 associated myopathy.

Tom Aschman1, Werner Stenzel

  • 1Department of Neuropathology, Charité - Universitätsmedizin, Berlin, Germany.

Current Opinion in Neurology
|August 11, 2022
PubMed
Summary
This summary is machine-generated.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause persistent muscle symptoms post-infection. These may stem from immune responses rather than direct viral muscle invasion, similar to other postinfectious syndromes.

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Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • The global spread of SARS-CoV-2 has led to widespread acute and postacute muscular symptoms.
  • Understanding the mechanisms behind these symptoms is crucial for patient management.

Purpose of the Study:

  • To review and decipher the potential pathomechanisms linking SARS-CoV-2 infection to muscle affection.
  • To summarize current findings on COVID-19-associated myopathy.

Main Methods:

  • Literature review of studies investigating muscle symptoms in COVID-19 patients.
  • Analysis of histopathological evidence and clinical presentations.
  • Comparison with postinfectious syndromes (PIS).

Main Results:

  • Direct evidence of myositis is primarily seen in deceased severe COVID-19 cases.
  • Postacute myalgia and weakness can persist for up to a year, resembling PIS.
  • COVID-19 myopathy likely involves heterogeneous, immune-mediated mechanisms, influenced by individual factors.

Conclusions:

  • COVID-19-associated myopathy is complex, with immune responses playing a probable role.
  • Distinguishing from other conditions like PIS and considering rheumatological/neurological differentials is important.
  • Further research is needed to fully elucidate the pathomechanisms and guide treatment.