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Post-COVID-19 outcomes of non-dialysis dependent chronic kidney disease patients: a national, multicenter, controlled

Serhat Karadag1, Savas Ozturk2, Mustafa Arici3

  • 1Department of Nephrology, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey.

International Urology and Nephrology
|August 11, 2022
PubMed

Insights

Patients with chronic kidney disease (CKD) who survived COVID-19 experienced higher mortality and worsening kidney function post-infection. This study highlights the significant long-term risks of COVID-19 for CKD patients not on dialysis.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • Chronic kidney disease (CKD) is a known risk factor for severe outcomes and mortality in Coronavirus disease 2019 (COVID-19).
  • Limited research exists on the post-COVID-19 prognosis for CKD patients, particularly those not requiring renal replacement therapy.
  • Understanding these outcomes is crucial for managing CKD patients during and after the pandemic.

Purpose of the Study:

  • To investigate the outcomes of CKD patients after surviving COVID-19.
  • To compare the post-COVID-19 period in CKD patients with a control group of CKD patients who did not contract COVID-19.
  • To assess kidney function, respiratory symptoms, dialysis requirements, and mortality rates.

Main Methods:

  • A multicenter observational study included CKD patients (GFR < 60 ml/min/1.73 m²) who survived COVID-19.
  • Exclusion criteria included CKD caused by diabetic nephropathy, polycystic kidney disease, and glomerulonephritis.
  • A control group of CKD patients with similar characteristics but no COVID-19 infection was used for comparison.

Main Results:

  • The COVID-19 group (173 patients) showed significantly higher creatinine levels at 1 month post-infection compared to the control group (207 patients).
  • Respiratory symptoms were more prevalent in the COVID-19 group at 1 and 3 months post-diagnosis.
  • Mortality at 3 months (5.2% vs. 1.4%) and the need for dialysis (8.1% vs. 3.4%) were significantly higher in the COVID-19 survivors.

Conclusions:

  • COVID-19 infection is associated with increased mortality in CKD patients.
  • Survivors of COVID-19 with CKD experience significant deterioration in kidney function and an increased need for dialysis post-infection.
  • CKD patients who contract COVID-19 are at higher risk for persistent respiratory symptoms.
Abstract

Keywords:
CKDCOVID-19Outcomes

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