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Updated: Sep 1, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.7K

Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells

Tsung-Jung Ho1,2,3, Debakshee Goswami4, Wei-Wen Kuo5

  • 1Department of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.

Aging
|August 11, 2022
PubMed

Insights

Artemisia argyi water extract (AAW) shows anti-aging effects by protecting stem cells from senescence. This natural compound improved health markers in aging rats, suggesting potential for longevity and age-related complication prevention.

Area of Science:

  • Gerontology and Regenerative Medicine
  • Cellular Biology and Aging
  • Natural Product Therapeutics

Background:

  • Aging leads to cellular pathway dysfunction and stem cell exhaustion, increasing age-related complication (ARC) risk.
  • Senotherapeutics are gaining interest for promoting healthy aging and treating ARCs.
  • Artemisia argyi is explored for its potential senomorphic properties and intervention in ARCs.

Purpose of the Study:

  • To evaluate the clinical efficacy of daily Artemisia argyi water extract (AAW) consumption on aging.
  • To investigate AAW's senomorphic properties and its potential as an anti-aging strategy.
  • To assess AAW's impact on stem cell health and age-related functional decline.

Main Methods:

  • *In vitro*: Human adipose-derived mesenchymal stem cells induced into senescence were treated with varying AAW concentrations.
  • *In vivo*: Aged Sprague Dawley rats were administered AAW for four weeks.
  • Evaluated effects on telomere shortening, protein expression (Klotho, TERT), mitochondrial superoxide, senescence markers (p21, double-strand breaks), cardiac function, grip strength, and memory.

Main Results:

  • *In vitro* studies demonstrated AAW's protective effects against telomere shortening and maintained balanced expression of Klotho and TERT.
  • AAW reduced mitochondrial superoxide and protected against senescence markers like p21 over-expression and DNA double-strand breaks.
  • Animal studies showed AAW increased Klotho expression, restored cardiac function, and improved grip strength and memory in aging rats.

Conclusions:

  • AAW exhibits significant anti-aging effects by protecting against cellular senescence and promoting stem cell homeostasis.
  • Daily consumption of AAW demonstrated therapeutic potential in improving age-related functional decline and overall health in aging rats.
  • Artemisia argyi water extract represents a promising natural intervention for promoting longevity and preventing age-related complications.
Keywords:
Artemisia argyianti-agingantioxidantklothostem cell

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