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Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Natriuretic Peptides (BNP)
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Peripheral Artery Disease III: Interprofessional Care01:27

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Hypertension I: Introduction01:28

Hypertension I: Introduction

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Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Related Experiment Video

Updated: Sep 1, 2025

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Cohort profile: The PreEclampsia, Angiogenesis, Cardiac dysfunction and Hypertension (PEACH) Study.

Lisa Kristine Grange Persson1,2, Frederikke Fog Lihme1, Saima Basit1

  • 1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

Paediatric and Perinatal Epidemiology
|August 11, 2022
PubMed
Summary

The PEACH Study aims to identify new subtypes of hypertensive disorders of pregnancy (HDP) and markers for future cardiovascular disease risk. This research will improve monitoring and treatment for pregnant women with HDP.

Keywords:
cardiovascular riskcohort studygestational hypertensionlongitudinal studypreeclampsiaprospective study

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Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Health
  • Perinatal Medicine

Background:

  • Hypertensive disorders of pregnancy (HDP) are a major cause of maternal mortality globally.
  • Preeclampsia, a common HDP, likely comprises multiple distinct subtypes with varying etiologies and prognoses.
  • HDP poses risks for both maternal and neonatal well-being and long-term cardiovascular health.

Purpose of the Study:

  • To establish novel subtyping systems for HDP based on etiology and prognosis.
  • To identify biomarkers associated with later cardiovascular disease risk in women with preeclampsia.
  • To understand the long-term cardiovascular health implications of HDP.

Main Methods:

  • The PEACH Study is a prospective, longitudinal pregnancy cohort study.
  • Recruitment involved pregnant women with suspected preeclampsia and healthy controls at two Copenhagen hospitals.
  • Data collection included third-trimester blood and placental samples, repeated cardiac function assessments (USCOM-1A), and medical record abstraction.

Main Results:

  • 1149 pregnant women were recruited between 2016-2018.
  • Among 691 women with suspected preeclampsia, 310 developed preeclampsia and 172 developed gestational hypertension.
  • Of 410 healthy controls, 37 later developed HDP; 53.1% participated in 1-year postpartum follow-up.

Conclusions:

  • The PEACH Study's data will facilitate the identification of clinically useful HDP subtypes for improved management.
  • Postpartum follow-up data will aid in developing algorithms to predict persistent cardiac dysfunction and future cardiovascular disease risk.
  • This research aims to enhance long-term cardiovascular health outcomes for women affected by HDP.