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Global prevalence of cerebral palsy: A systematic analysis

Sarah McIntyre1, Shona Goldsmith1, Annabel Webb1

  • 1Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Developmental Medicine and Child Neurology
|August 11, 2022
PubMed

Insights

Cerebral palsy (CP) birth prevalence is decreasing in high-income countries, now at 1.6 per 1000 live births. However, prevalence in low- and middle-income countries remains markedly higher, with trends yet to be measured.

Area of Science:

  • Neurology
  • Public Health
  • Epidemiology

Background:

  • Cerebral palsy (CP) is a group of disorders affecting movement and posture, with varying prevalence globally.
  • Understanding CP trends is crucial for public health planning and resource allocation.

Purpose of the Study:

  • To determine current global and regional prevalence estimates of cerebral palsy (CP).
  • To analyze trends in CP prevalence, distinguishing between pre-/perinatal, postnatal, neonatal, and overall cases.

Main Methods:

  • Systematic analysis of data from 41 regions across 27 countries, utilizing CP registers, surveillance systems, and population-based studies (birth year 1995 onwards).
  • Quality and risk of bias assessments were performed. Meta-analyses were conducted for prevalence estimates from birth year 2010 onwards.

Main Results:

  • Pre-/perinatal CP birth prevalence significantly declined in 11 out of 14 European and Australian regions.
  • Current overall CP birth prevalence in high-income countries (HICs) is 1.6 per 1000 live births.
  • Data from low- and middle-income countries (LMICs) indicate markedly higher birth prevalence, with pre-/perinatal CP as high as 3.4 per 1000 live births.

Conclusions:

  • CP birth prevalence is declining in HICs, but remains significantly higher in LMICs.
  • Active surveillance and population-based data are essential for informing policy and assessing the impact of interventions.
Abstract

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