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Updated: Jul 6, 2026

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
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Cu2+ ions modulate the interaction between α-synuclein and lipid membranes.

Hongzhi Wang1, Cecilia Mörman2, Rebecca Sternke-Hoffmann1

  • 1Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.

Journal of Inorganic Biochemistry
|August 11, 2022
PubMed
Summary

Copper ions and lipid membranes influence alpha-synuclein aggregation, a key factor in Parkinson's disease. This study reveals how these factors interact, offering insights into disease mechanisms.

Keywords:
Cu(2+) ionsIn-cell NMRLCPParkinson's diseaseSAXSα-Synuclein

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