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Updated: Sep 1, 2025
Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
Diagnostic capacity of sFlt-1/PlGF ratio in fetal growth restriction: A systematic review and meta-analysis
Wenjing Chen1, Qing Wei1, Qian Liang1
1Department of Obstetrics and Gynecology, The Third Central Hospital of Tianjin, Tianjin, China; Department of Obstetrics and Gynecology, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin, China; Department of Obstetrics and Gynecology, Artificial Cell Engineering Technology Research Center, Tianjin, China; Department of Obstetrics and Gynecology, Tianjin Institute of Hepatobiliary Disease, Tianjin, China.
Introduction:
We aimed to systemically investigate the diagnostic capacity of soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio in fetal growth restriction (FGR).
Methods:
We systematically searched the PubMed, MEDLINE, Cochrane Library, and EMBASE databases for relevant studies from inception to 15 May 2022. All potentially relevant studies were assessed and then pooled.
Results:
Eight studies with 339 patients and 5111 controls were included. A sFlt-1/PlGF ratio >33 was demonstrated a predictive value for FGR with a pooled sensitivity of [0.63, 95% confidence interval (CI) = 0.54-0.71], specificity of (0.84, 95% CI = 0.83-0.85), and area under the curve (AUC) of 0.8354. The pooled sensitivity, specificity, and AUC for the sFlt-1/PlGF ratio ≥85 group were 0.79 (95% CI = 0.66-0.89), 0.69 (95% CI = 0.65-0.74), and 0.8197, respectively.
Discussion:
These findings revealed that the sFlt-1/PlGF ratio could be a potential indicator in predicting FGR and FGR + PE. More studies are needed to support the conclusion.
