[Translated article] Chronic Nodular Prurigo: A Retrospective Study of 74 Cases

Area of Science:

• Dermatology
• Immunology
• Internal Medicine

Background:

• Chronic nodular prurigo (CNPG) is a complex, underdiagnosed dermatological condition.
• CNPG is associated with numerous comorbidities, impacting patient health.
• Understanding CNPG pathogenesis has improved its management and treatment.

Purpose of the Study:

• To describe the sociodemographic and clinical characteristics of patients with CNPG.
• To report on the diagnostic methods and treatment outcomes for CNPG.
• To evaluate the effectiveness of different treatment modalities for CNPG.

Main Methods:

• Single-center, observational, retrospective study.
• Inclusion of 74 patients diagnosed with CNPG between 2009 and 2021.
• Analysis of sociodemographic data, comorbidities, diagnostic methods (including skin biopsy), and treatment regimens.

Main Results:

• The study included 74 patients, predominantly women (63.5%), with a mean age of 57.
• High prevalence of comorbidities: endocrine (54.1%), cardiovascular (44.4%), and psychiatric (36.5%).
• Elevated mean IgE levels (516 IU/mL); methotrexate identified as an effective treatment option.

Conclusions:

• CNPG is a complex disease requiring a multidisciplinary approach, with dermatologists playing a central role.
• The high comorbidity burden in CNPG patients necessitates comprehensive care.
• Standard treatment strategies for CNPG may be insufficient, highlighting the need for advanced therapeutic options.