[Translated article] COVID-19 and Dermal Fillers: Should We Really Be Concerned?

Area of Science:

• Dermatology
• Immunology
• Infectious Diseases

Background:

• SARS-CoV-2 has caused a global health crisis with significant morbidity and mortality.
• Delayed inflammatory reactions, particularly in facial hyaluronic acid dermal fillers, have been observed post-SARS-CoV-2 infection and vaccination.
• These reactions, though often self-limiting, are classified as serious adverse events by the US FDA.

Purpose of the Study:

• To investigate the occurrence and characteristics of delayed inflammatory reactions associated with hyaluronic acid dermal fillers following SARS-CoV-2 infection and vaccination.
• To highlight the importance of diagnosis and management of these filler complications.
• To emphasize the need for further research into the underlying immunological mechanisms and long-term effects.

Main Methods:

• Observational reports and clinical case reviews of patients experiencing delayed inflammatory reactions post-SARS-CoV-2 infection or vaccination.
• Analysis of clinical presentation, timing of onset, and response to treatment.
• Literature review on hypersensitivity reactions and dermal filler complications.

Main Results:

• Delayed inflammatory reactions to hyaluronic acid fillers present primarily in the face after SARS-CoV-2 infection or vaccination.
• These reactions are suspected to be type IV hypersensitivity responses triggered by viral presence.
• While generally not severe, treatment with corticosteroids, hyaluronidase, or antibiotics may be necessary.

Conclusions:

• Delayed inflammatory reactions to hyaluronic acid fillers are a recognized complication of SARS-CoV-2 infection and vaccination.
• Understanding the immunological mechanisms is crucial for managing these events and potentially preventing future occurrences.
• Continued monitoring and reporting of these adverse events are essential, especially with evolving pandemic dynamics and increasing use of long-lasting fillers.