Related Experiment Video
Updated: Sep 1, 2025

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Mitral Valve Dysfunction in Patients With Annular Calcification: JACC Review Topic of the Week
Timothy W Churchill1, Evin Yucel2, Sébastien Deferm3
1Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: https://twitter.com/TimChurchillMD.
Abstract:
Mitral annular calcification (MAC) is a common clinical finding and is associated with adverse clinical outcomes, but the clinical impact of MAC-related mitral valve (MV) dysfunction remains underappreciated. Patients with MAC frequently have stenotic, regurgitant, or mixed valvular disease, and this valvular dysfunction is increasingly recognized to be independently associated with worse prognosis. MAC-related MV dysfunction is a distinct pathophysiologic entity, and importantly much of the diagnostic and therapeutic paradigm from published rheumatic MV disease research cannot be applied in this context, leaving important gaps in our knowledge. This review summarizes the current epidemiology, pathophysiology, diagnosis, and classification of MAC-related MV dysfunction and proposes both an integrative definition and an overarching approach to this important and increasingly recognized clinical condition.
More Related Videos
Related Concept Videos
Mitral Regurgitation III: Medical Management
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation I: Introduction
Mitral Valve Prolapse I: Introduction
Aortic Regurgitation III: Medical Management
Mitral Stenosis III: Medical Management

