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Characterization of native pathogenic antigens of Onchocerca volvulus: identification of high molecular mass protein antigens eliciting interstitial keratitis in a guinea pig model.

Experimental eye research·1995
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Infiltration of CD4+ T cells into cornea during development of Onchocerca volvulus-induced experimental sclerosing keratitis in mice.

Cellular immunology·1994
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The Onchocerca volvulus homologue of the multifunctional polypeptide protein disulfide isomerase.

Molecular and biochemical parasitology·1994
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Prevalence of hypertension in rural west Africa.

The American journal of the medical sciences·1994
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Immune-mediated Onchocerca volvulus sclerosing keratitis in the mouse.

Experimental eye research·1993
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Experimental onchocerciasis in chimpanzees: cellular responses and antigen recognition after immunization and challenge with Onchocerca volvulus infective third-stage larvae.

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Primate model for onchocerciasis research.

B M Greene

    Ciba Foundation Symposium
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Chimpanzees can be infected with Onchocerca volvulus, serving as a valuable animal model for onchocerciasis research. This model shows immune responses similar to humans, aiding in drug development and disease understanding.

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    Area of Science:

    • Parasitology
    • Immunology
    • Tropical Medicine

    Background:

    • Onchocerciasis research is hindered by the absence of a suitable animal model.
    • Chimpanzees offer a promising model, exhibiting infection patterns similar to humans.

    Purpose of the Study:

    • To establish and characterize a chimpanzee model for Onchocerca volvulus infection.
    • To investigate the immune responses in infected chimpanzees and the effect of ivermectin.

    Main Methods:

    • Eighteen chimpanzees were infected with third-stage larvae of O. volvulus.
    • Groups received ivermectin at different time points or no drug; controls were uninfected.
    • Lymphocyte blastogenic responses and antibody levels were monitored.

    Main Results:

    • Infected chimpanzees showed increased lymphocyte responses to O. volvulus antigen.
    • Antibody responses increased over time in infected animals.
    • Ivermectin's effects on infection progression are under evaluation.

    Conclusions:

    • Chimpanzees represent a viable animal model for studying onchocerciasis.
    • The model demonstrates key immunological features of human infection.
    • Further studies will elucidate ivermectin's impact on the infection course.