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Consensus statement on blocking interleukin-6 receptor and interleukin-6 in inflammatory conditions: an update
Daniel Aletaha1, Andreas Kerschbaumer2, Kastriot Kastrati2
1Division of Rheumatology, Medical University of Vienna, Wien, Austria daniel.aletaha@meduniwien.ac.at.
Interleukin-6 (IL-6) pathway inhibitors are crucial for treating inflammatory diseases. This updated consensus provides guidance on their medical use, covering dosing, safety, and monitoring for various conditions.
Area of Science:
- Immunology
- Pharmacology
- Rheumatology
Background:
- Interleukin-6 (IL-6) pathway inhibition is a key strategy for immune-mediated inflammatory diseases.
- Therapeutic approaches include anti-IL-6 receptor antibodies and direct IL-6 cytokine inhibition.
- This document updates previous consensus based on recent evidence and expert opinion.
Framework:
- Systematic literature review on IL-6 pathway inhibitors in inflammatory diseases.
- International expert and patient consensus process to contextualize evidence.
- Development of consensus statements and the current document.
Implementation:
- Covers approved IL-6 pathway inhibitors for conditions like rheumatoid arthritis, juvenile idiopathic arthritis, giant cell arteritis, and COVID-19.
- Addresses dosing, patient populations, pretreatment screening, safety, contraindications, and monitoring.
- Includes specific indications such as adult-onset Still's disease, Castleman's disease, CAR-T CRS, and neuromyelitis optica spectrum disorder.
Implications:
- Provides comprehensive consensus on IL-6 inhibition for inflammatory disorders.
- Aims to inform healthcare professionals, researchers, patients, administrators, and payers.
- Facilitates optimal and safe utilization of IL-6 pathway inhibitors in clinical practice.
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