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Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression
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Therapeutic strategies to address monkeypox.

Matthew W McCarthy1

  • 1Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Expert Review of Anti-Infective Therapy
|August 11, 2022
PubMed
Summary

Monkeypox, a viral disease, is spreading globally. This review examines potential smallpox therapeutics, like tecovirimat and brincidofovir, for treating the expanding monkeypox pandemic.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Monkeypox is a viral zoonosis with symptoms resembling smallpox, historically rare and confined to Africa.
  • An international outbreak began in May 2022, rapidly spreading globally and declared a public health emergency by the WHO.
  • No specific treatments exist for monkeypox, but smallpox therapeutics may be effective due to viral similarities.

Purpose of the Study:

  • To review current knowledge on potential monkeypox virus treatments.
  • To explore the use of smallpox therapeutics, such as tecovirimat and brincidofovir, for the ongoing monkeypox outbreak.

Main Methods:

  • Literature search of PubMed for studies on monkeypox and smallpox therapeutics up to August 9, 2022.
  • Review of existing data on tecovirimat and brincidofovir efficacy and application.
Keywords:
Monkeypoxbrincidofovirsars-cov-2smallpoxtecovirimat

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Main Results:

  • Monkeypox and smallpox viruses share genetic similarities, suggesting cross-efficacy of treatments.
  • Tecovirimat and brincidofovir are identified as potential therapeutics for monkeypox.
  • The review synthesizes current understanding of these treatments for the global monkeypox pandemic.

Conclusions:

  • Tecovirimat and brincidofovir show promise as treatments for monkeypox virus infections.
  • Further research and clinical application of these therapeutics are crucial for managing the expanding monkeypox pandemic.
  • The genetic similarity between monkeypox and smallpox viruses supports the repurposing of smallpox therapeutics.