Related Experiment Video

Updated: Sep 1, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Interplay of Developmental Hippo-Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer

Ioanna Mourkioti1, Andriani Angelopoulou1, Konstantinos Belogiannis1

  • 1Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.

Cells
|August 12, 2022
PubMed

Insights

Prostate cancer progresses to a deadly form when cells resist androgen deprivation therapy. Understanding DNA damage response, Hippo, and Notch pathways may reveal new therapeutic targets for advanced prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling Pathways

Background:

  • Prostate cancer is a major male cancer, initially dependent on androgen receptor (AR) signaling.
  • Androgen deprivation therapy (ADT) is the primary treatment, but often leads to castration-resistant prostate cancer (CRPC).
  • CRPC is aggressive with a poor prognosis, necessitating research into progression mechanisms.

Purpose of the Study:

  • To elucidate molecular mechanisms driving prostate cancer progression to CRPC.
  • To review the roles of DNA damage response (DDR), Hippo, and Notch pathways in prostate tumorigenesis.
  • To identify potential novel therapeutic targets within these signaling pathways.

Main Methods:

  • Literature review of signaling pathways in prostate cancer.
  • Analysis of crosstalk between DDR, Hippo, Notch, and AR signaling.
  • Evaluation of the clinical impact of these pathway interactions.

Main Results:

  • The review highlights the interplay between DDR, Hippo, and Notch pathways in prostate cancer.
  • Evidence demonstrates crosstalk between these pathways and AR signaling.
  • These interactions are crucial for understanding prostate cancer progression.

Conclusions:

  • The complex interplay of DDR, Hippo, and Notch pathways is central to prostate tumorigenesis.
  • Understanding these interactions may reveal novel therapeutic strategies.
  • Targeting molecules within the DDR-Hippo-Notch network offers potential for combating advanced prostate cancer.
Keywords:
DNA damage response (DDR)Hippo pathwayNotch pathwayinterplayprostate cancer

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