Related Experiment Video
Updated: Sep 1, 2025

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
Published on: July 7, 2023
The Effect of Positive Intervention Dosing Frequency: Fixed Intervals May Decrease More Depression than Flexible Ones
1Department of Counseling and Applied Psychology, National Taichung University of Education, Taichung 40306, Taiwan.
Abstract:
Positive interventions (PIs) that are based on the theory of positive psychology have proven to be effective in improving well-being and alleviating depression. However, little research has explored the effect of dosing intervals on experimental effects. As such, this study designed strength-based PIs using cognitive reframing theory and compared flexible and fixed dosing intervals to find out which one could more effectively reduce depression with equal total amounts of dosing. The 8-item Center for Epidemiological Studies Depression Scale (8-item CES-D) and the Positive reframing scale (PRS) were adopted as research instruments. A total of 193 Taiwanese college students were recruited as the research sample and they were randomly assigned to experimental Group A (fixed dosing intervals), experimental Group B (flexible dosing intervals), and the Control Group. The research participants received 17-day interventions with follow-up tests administered in the seventh week of the experiment. Ultimately, 157 participants completed the experiment. According to the ANCOVA results, participants in experimental Group A showed significantly lower degrees of depression than those in the Control Group in both post-test and follow-up stages and displayed greater effect size in the follow-up stage than in the post-test stage. The results indicated that the design of fixed dosing intervals enabled the participants to effectively integrate reflections on reframing learned during PIs into their life. On the contrary, participants in experimental Group B exhibited no significant difference in the degree of depression from those in the Control Group during either the post-test or follow-up stage and manifested poorer effects in the follow-up stage than in the post-test stage. These results demonstrated that fixed dosing intervals achieved better effects than flexible dosing intervals. Participants receiving fixed dosing intervals could more effectively execute cognitive reframing and showed longer-lasting experimental effects, whereas participants using the design of flexible dosing intervals were more prone to forget to implement PIs and attain less positive effects as a result.
More Related Videos
Related Concept Videos
Dosage Regimen: Fixed Dose
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Antidepressant Drugs: MAOIs and Other Agents
Rational Dosage Regimen: Maintenance Dose and Loading Dose
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
Depressive Disorders: MDD and Dysthymia
Antidepressant Drugs: Overview
The Placebo Effect

