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Current Knowledge in Skin Metabolomics: Updates from Literature Review
Alessia Paganelli1,2, Valeria Righi3, Elisabetta Tarentini4
1Clinical and Experimental Medicine Ph.D. Program, University of Modena and Reggio Emilia, 41124 Modena, Italy.
International Journal of Molecular Sciences
|August 12, 2022
Summary
Skin metabolomics analyzes metabolites for diagnosing and treating skin conditions. This review covers 97 studies, highlighting its use in inflammatory, immune-mediated, and skin cancer research.
Area of Science:
- Dermatology
- Metabolomics
- Biomarker Discovery
Background:
- Metabolomic profiling measures metabolites, offering insights into biological systems.
- Metabolic patterns are linked to pathological processes, including skin disorders.
- Skin metabolomics can identify biomarkers for diagnosis, prognosis, and therapy.
Purpose of the Study:
- To provide a comprehensive overview of published research in skin metabolomics.
- To synthesize findings from studies on skin metabolite alterations in various dermatological conditions.
Main Methods:
- Systematic literature search of MEDLINE, EMBASE, Cochrane, and Scopus databases.
- Inclusion of English full-text research articles, excluding studies on cutaneous microbiomes.
- Analysis of 97 selected papers meeting all search criteria.
Main Results:
- The majority of studies focused on inflammatory and immune-mediated dermatoses.
- Skin oncology emerged as a significant area of metabolomic research.
- Limited research was found on infectious diseases and rare genetic skin disorders.
Conclusions:
- Skin metabolomics is a valuable tool for understanding and managing dermatological diseases.
- Metabolomic alterations are key indicators in inflammatory, immune-mediated, and oncological skin conditions.
- Further research is warranted for infectious and genetic dermatoses.
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