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Relationship between Pachychoroid and Polypoidal Choroidal Vasculopathy.

Kenji Yamashiro1,2, Yasuo Yanagi3,4,5, Hideki Koizumi6

  • 1Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Nankoku 7838505, Japan.

Journal of Clinical Medicine
|August 12, 2022
PubMed
Summary

Pachychoroid may cause macular neovascularization (MNV), leading to pachychoroid neovasculopathy (PNV) and polypoidal choroidal vasculopathy (PCV). Current classifications hinder understanding, necessitating a refined framework for PNV, PCV, and neovascular age-related macular degeneration (nAMD).

Keywords:
age-related macular degenerationdrusen-driven diseasepachychoroid neovasculopathypachychoroid-driven diseasepolypoidal choroidal vasculopathy

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Choroidal Neovascularization

Background:

  • Pachychoroid is linked to macular neovascularization (MNV), potentially causing pachychoroid neovasculopathy (PNV) and polypoidal choroidal vasculopathy (PCV).
  • Existing research on PNV and PCV uses varied classification systems, impeding a unified understanding.
  • The relationship between PNV and PCV, and whether PCV is a subset of PNV, remains debated.

Purpose of the Study:

  • To review and synthesize existing literature on polypoidal choroidal vasculopathy (PCV) and the pachychoroid concept.
  • To clarify the relationship between pachychoroid neovasculopathy (PNV), PCV, and neovascular age-related macular degeneration (nAMD).
  • To propose a refined conceptual framework for future research into these conditions.

Main Methods:

  • Comprehensive literature review of studies on PCV and pachychoroid.
  • Analysis of historical and recent research regarding classification systems for PNV, PCV, and nAMD.
  • Synthesis of findings to identify inconsistencies and propose a unified framework.

Main Results:

  • Evidence suggests PCV may have subtypes, with some exhibiting pachychoroid features, even predating the pachychoroid concept.
  • Previous studies offer insights into the connection between PCV and PNV.
  • Inconsistent definitions and classifications of PNV and PCV exist in current literature.

Conclusions:

  • A refined conceptual framework is needed for studying PNV, PCV, and nAMD.
  • Caution is advised when using the term PCV due to the current lack of consistent understanding.
  • Further research is required to elucidate the precise nature of PCV and its relationship with pachychoroid and PNV.