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microRNAs in Subarachnoid Hemorrhage (Review of Literature)
Marianna Makowska1, Beata Smolarz2, Hanna Romanowicz2
1Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Intensive Care Medicine, Augustenburger Platz 1, 13353 Berlin, Germany.
Abstract:
Recently, many studies have shown that microRNAs (miRNAs) in extracellular bioliquids are strongly associated with subarachnoid hemorrhage (SAH) and its complications. The article presents issues related to the occurrence of subarachnoid hemorrhage (epidemiology, symptoms, differential diagnosis, examination, and treatment of the patient) and a review of current research on the correlation between miRNAs and the complications of SAH. The potential use of miRNAs as biomarkers in the treatment of SAH is presented.
Insights
MicroRNAs (miRNAs) in extracellular fluids show strong links to subarachnoid hemorrhage (SAH) and its complications. These miRNAs may serve as valuable biomarkers for diagnosing and managing SAH patients.
Area of Science:
- Neuroscience
- Biochemistry
- Genetics
Background:
- Subarachnoid hemorrhage (SAH) is a critical neurological condition with significant morbidity and mortality.
- Extracellular microRNAs (miRNAs) are increasingly recognized as crucial regulators in various biological processes and disease states.
- Recent research highlights the association between circulating miRNAs and SAH complications.
Purpose of the Study:
- To review the epidemiology, symptoms, diagnosis, and treatment of subarachnoid hemorrhage.
- To consolidate current research on the correlation between microRNAs and SAH complications.
- To explore the potential of miRNAs as diagnostic and prognostic biomarkers for SAH.
Main Methods:
- Literature review of epidemiological data on SAH.
- Analysis of current research on miRNA expression in SAH.
- Review of studies investigating miRNA as biomarkers for SAH complications.
Main Results:
- SAH presents with specific clinical features, requiring prompt diagnosis and management.
- A growing body of evidence links specific miRNAs to the development and progression of SAH complications.
- miRNAs show promise as non-invasive biomarkers for SAH detection and monitoring.
Conclusions:
- MicroRNAs in extracellular fluids represent a significant area of research for understanding SAH.
- miRNAs hold potential as reliable biomarkers for early detection and personalized treatment strategies in SAH.
- Further research is warranted to translate miRNA findings into clinical applications for SAH management.
