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Effects of Green Tea and Green Tea Incorporated in Nanoparticle Lyotropic Liquid Crystal on Exercise Adaptations: A
Vitor Nieri1, Juliana Ferreira de Souza2, Talita Cristina Mena Segato1
1Laboratory of Toxicologycal Research, University of Sorocaba, UNISO, Sorocaba 18023-000, SP, Brazil.
Green tea nanoparticles enhanced bioavailability, improving exercise outcomes. Lyotropic liquid crystals (LLCs) with green tea (GT) boosted muscle hypertrophy and physical conditioning in rats undergoing high-intensity interval training (HIIT).
Area of Science:
- Biochemistry
- Exercise Physiology
- Nanotechnology
Background:
- Green tea (GT) is a potent natural antioxidant, but its efficacy is limited by oxidation post-preparation.
- Lyotropic liquid crystals (LLCs) offer a nanostructured system for incorporating and stabilizing bioactive compounds like GT.
- High-intensity interval training (HIIT) elevates reactive oxygen species (ROS) production, necessitating effective antioxidant strategies.
Purpose of the Study:
- To investigate the comparative effects of free green tea (GT) versus GT encapsulated in lyotropic liquid crystals (GT-NP-LLC) on rats subjected to high-intensity interval training (HIIT).
- To evaluate the impact on hematological, biochemical, histological parameters, redox status, and body mass.
- To assess the potential of NP-LLC to enhance GT bioavailability and efficacy.
Main Methods:
- Nanoparticles of LLC (NP-LLC) were formulated using monoolein, GT infusion, and Poloxamer 407.
- Healthy male rats were divided into six groups: Control, GT, GT-NP-LLC, Exercise (Ex), GT+Ex, and GT-NP-LLC+Ex.
- Parameters assessed included body mass, triglycerides, muscle hypertrophy, physical conditioning, and redox status.
Main Results:
- HIIT significantly reduced body weight across all exercise groups.
- GT-NP-LLC and Ex groups showed reduced triglyceride levels compared to the control.
- Combined GT or GT-NP-LLC supplementation with HIIT resulted in greater muscle hypertrophy (25% and 21%, respectively) and improved physical conditioning compared to HIIT alone.
Conclusions:
- GT-NP-LLC supplementation, particularly when combined with HIIT, enhances muscle hypertrophy and physical conditioning.
- The NP-LLC formulation shows promise in improving the bioavailability and effectiveness of GT.
- This study suggests that GT-NP-LLC is a potentially superior antioxidant strategy for mitigating exercise-induced oxidative stress.
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