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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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HIF in Gastric Cancer: Regulation and Therapeutic Target

Mengqing Li1,2, Guan Li3, Xiaodong Yang1

  • 1Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research, Department of Oncology, Peking University Shenzhen Hospital, Cancer Institute of Shenzhen-PKU-HKUST Medical Center, Shenzhen 518036, China.

Molecules (Basel, Switzerland)
|August 12, 2022
PubMed

Insights

Hypoxia-inducible factor (HIF) plays a key role in tumor development. This review explores HIF

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The hypoxia-inducible factor (HIF) gene family regulates critical biological processes, including tumor development.
  • Gastric cancer is a leading cause of cancer-related mortality globally, with poor survival rates for advanced stages.
  • The FDA-approved drug Welireg targeting HIF-2a for von Hippel-Lindau syndrome highlights the therapeutic potential of HIF inhibition in oncology.

Purpose of the Study:

  • To review the regulatory and target roles of HIF in gastric cancer.
  • To provide insights into potential HIF-targeted therapies for gastric cancer treatment.

Main Methods:

  • Literature review of studies on HIF in gastric cancer.
  • Analysis of HIF's involvement in gastric cancer progression and therapeutic strategies.

Main Results:

  • HIF is implicated in various aspects of tumor development and progression in gastric cancer.
  • Targeting HIF, particularly HIF-2a, shows promise for cancer therapy.

Conclusions:

  • HIF represents a significant therapeutic target for gastric cancer.
  • Further research into HIF-directed treatments could improve outcomes for advanced gastric cancer patients.
Keywords:
HIFgastric cancer

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