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Updated: Sep 1, 2025

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
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Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases

Qing Yue1, Yu Song1, Zi Liu1

  • 1Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.

Molecules (Basel, Switzerland)
|August 12, 2022
PubMed

Insights

The receptor for advanced glycation end products (RAGE) pathway is crucial in immune diseases. Targeting RAGE offers potential therapeutic strategies for conditions like lupus and Alzheimer's disease.

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • The receptor for advanced glycation end products (RAGE) is a key mediator in inflammatory responses.
  • RAGE ligands include advanced glycation end products (AGEs), S100 proteins, and high-mobility group protein 1 (HMGB1).
  • RAGE signaling is implicated in various immune-related diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Alzheimer's disease.

Purpose of the Study:

  • To systematically analyze RAGE-related signaling pathways and their regulatory mechanisms in immune-related diseases.
  • To explore the therapeutic potential of targeting RAGE signaling pathways.

Main Methods:

  • Review and synthesis of existing literature on RAGE signaling.
  • Analysis of RAGE's role in the pathogenesis of immune-related diseases.
  • Examination of RAGE's involvement in cellular processes like inflammation, apoptosis, autophagy, and endoplasmic reticulum stress.

Main Results:

  • RAGE activation initiates intracellular cascades, affecting signal transduction and cytokine release.
  • RAGE signaling pathways are integral to the development and progression of multiple immune-related diseases.
  • Intervention in RAGE pathways demonstrates significant therapeutic promise.

Conclusions:

  • Targeting RAGE signaling pathways presents a viable therapeutic strategy for RAGE-mediated diseases.
  • Understanding RAGE's regulatory mechanisms provides theoretical basis for future drug development.
  • Further research into RAGE pathways can lead to novel treatments for inflammatory and immune disorders.
Keywords:
advanced glycation end-product receptorhigh-mobility group protein 1immunenuclear factor kappa-B

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