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An LSPR Sensor Integrated with VCSEL and Microfluidic Chip.

Fang Cao1, Xupeng Zhao1, Xiaoqing Lv2

  • 1Key Laboratory of Optoelectronics Technology, Ministry of Education, Beijing University of Technology, Beijing 100124, China.

Nanomaterials (Basel, Switzerland)
|August 12, 2022
PubMed
Summary

This study presents a novel localized surface plasmon resonance (LSPR) sensor chip using vertical-cavity surface-emitting lasers (VCSELs). The LSPR sensor demonstrates high sensitivity for refractive index detection, showing potential for biomolecular applications.

Keywords:
VCSELanodic aluminum oxide filmlocalized surface plasmon resonance (LSPR)microfluidicsensor

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Area of Science:

  • Nanotechnology
  • Optoelectronics
  • Biosensing

Background:

  • Localized surface plasmon resonance (LSPR) sensors offer high sensitivity for detecting changes in the local refractive index.
  • Vertical-cavity surface-emitting lasers (VCSELs) provide a compact and efficient light source for optical sensing applications.
  • Integrating nanostructures with microfluidics enhances the performance and applicability of sensing platforms.

Purpose of the Study:

  • To develop and characterize a novel LSPR sensor chip integrated with VCSELs.
  • To investigate the sensor's performance in detecting refractive index changes using a microfluidic system.
  • To model and simulate the optical properties of the gold nanostructures using the finite-difference time-domain (FDTD) algorithm.

Main Methods:

  • Fabrication of a hexagonal gold nanoparticle array on an anodic aluminum oxide (AAO) mask.
  • Integration of the nanostructure array with the light-emitting facet of a VCSEL.
  • Performance evaluation using refractive index sensing tests with sucrose solutions and microfluidic technology.
  • Numerical simulation of gold nanostructures using the FDTD algorithm.

Main Results:

  • The sensor's output power was correlated with the refractive index of sucrose solutions.
  • A maximum sensitivity of 1.65 × 10^6 nW/RIU was achieved.
  • The FDTD simulations provided insights into the optical behavior of the gold nanostructures.

Conclusions:

  • The developed VCSEL-integrated LSPR sensor chip is effective for refractive index sensing.
  • The sensor exhibits high sensitivity, indicating significant potential for biomolecular detection.
  • The combination of LSPR, VCSELs, and microfluidics offers a promising platform for advanced sensing applications.