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Influence of Breast Reduction Surgery on Long-Term Breast Cancer Risk in Austria
Albert Niepel1, Sven Schwake1, Mira Zeichmann2
1Department for Plastic and Reconstructive Surgery, Klinik Landstrasse, Vienna, Austria.
Breast Care (Basel, Switzerland)
|August 12, 2022
Summary
Women undergoing breast reduction surgery (reductive mammoplasty) experienced a significant decrease in breast cancer risk, with an 82% reduction observed compared to the general Austrian female population. Further research into surgical techniques is recommended.
Area of Science:
- Oncology
- Plastic Surgery
- Epidemiology
Background:
- Breast reduction surgery (reductive mammoplasty) is a common procedure worldwide.
- Prior research suggests a reduced risk of breast cancer development post-reduction mammoplasty.
- The exact magnitude of this risk reduction requires further investigation.
Purpose of the Study:
- To evaluate the relative risk of breast cancer development in patients who underwent breast reduction surgery.
- To compare breast cancer incidence in a cohort of Austrian women who had breast reduction surgery against the general female population of Austria.
Main Methods:
- A cohort of 513 women who underwent breast reduction surgery between 2003 and 2017 was analyzed.
- Standardized incidence ratio (SIR) and Poisson tests were used to compare the observed breast cancer cases to expected rates.
- Age-specific incidence rate data from the general Austrian female population served as the control group.
Main Results:
- Only one case of breast cancer was observed in the study cohort, compared to an expected 5.66 cases (SIR = 0.1765).
- This represents a statistically significant reduction in breast cancer incidence of approximately 82% (p = 0.023).
Conclusions:
- The study provides strong evidence supporting a significant reduction in breast cancer risk following reductive mammoplasty.
- The findings suggest that surgical techniques may influence breast cancer risk reduction.
- Further research is warranted to explore the impact of different surgical techniques on breast cancer prevention.
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