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Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence
Weili Xia1, Yong Xu1, Yuandong Gong1
1Shandong Mental Health Center, Shandong University, Jinan, Shandong 250014, China.
Abstract:
Poststroke depression (PSD) does not exist before and occurs after the stroke. PSD can appear shortly after the onset of stroke or be observed in the weeks and months after the acute or subacute phase of stroke. The pathogenesis of PSD is unclear, resulting in poor treatment effects. With research advancement, immunoactive cells in the central nervous system, particularly microglia, play a role in the occurrence and development of PSD. Microglia affects the homeostasis of the central nervous system through various factors, leading to the occurrence of depression. The research progress of microglia in PSD has been summarized to review the evidence regarding the pathogenesis and treatment target of PSD in the future.
Insights
Poststroke depression (PSD) is a condition that occurs after a stroke. Emerging research suggests microglia, immune cells in the brain, are key to understanding PSD
Area of Science:
- Neuroscience
- Immunology
- Psychiatry
Background:
- Poststroke depression (PSD) is a common complication following a stroke.
- The exact causes of PSD remain unclear, leading to challenges in effective treatment.
- Microglia, the brain's immune cells, are increasingly implicated in PSD development.
Purpose of the Study:
- To review the current research on the role of microglia in the pathogenesis of poststroke depression.
- To explore microglia as a potential therapeutic target for PSD.
Main Methods:
- Literature review of studies investigating microglia and PSD.
- Analysis of mechanisms by which microglia influence central nervous system homeostasis.
- Synthesis of evidence linking microglial activity to depressive symptoms poststroke.
Main Results:
- Microglia play a significant role in the occurrence and progression of PSD.
- Dysregulation of microglial function impacts the central nervous system's balance.
- Specific microglial factors contribute to the development of depression after stroke.
Conclusions:
- Microglia are critical players in the pathogenesis of poststroke depression.
- Targeting microglial pathways may offer novel therapeutic strategies for PSD.
- Further research into microglia-specific mechanisms is needed for improved PSD treatment.
