Related Experiment Video
Updated: Sep 1, 2025

11:44
A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
Published on: January 24, 2016
12.0K
Erratum: Dual Feedforward Loops Modulate Type I Interferon Responses and Induce Selective Gene Expression during TLR4
Iscience
|August 12, 2022
Summary
This study corrects a previous article DOI. The corrected DOI is 10.1016/j.isci.2020.100881.
Area of Science:
- Scientific publishing
- Article correction
- Digital Object Identifier (DOI)
Context:
- Ensuring accuracy in scientific literature
- Maintaining the integrity of research records
- Facilitating proper citation and retrieval of scientific articles
Purpose:
- To provide the correct Digital Object Identifier (DOI) for a specific scientific article
- To rectify an error in the previously published article information
- To ensure readers can access the intended research paper
Summary:
- The article DOI has been corrected to 10.1016/j.isci.2020.100881.
- This correction ensures the accurate identification and retrieval of the research.
- The original article content remains unchanged, only its identifier is updated.
Impact:
- Improved accessibility to the scientific article
- Enhanced data integrity within scientific databases
- Facilitation of accurate citation and referencing by researchers
Related Concept Videos
Cell Signaling Feedback Loops
6.5K
Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
6.5K
Positive and Negative Feedback Loops
20.0K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires maintaining an internal dynamic equilibrium:
20.0K
Immune Response Against Viral Pathogens
898
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
898
Feedback Loops
58.2K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
58.2K
Inflammatory Response
5.6K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
5.6K
Regulation of the Unfolded Protein Response
2.6K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.6K

