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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
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TGA transcription factors-Structural characteristics as basis for functional variability
Špela Tomaž1,2, Kristina Gruden1, Anna Coll1
1Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia.
Frontiers in Plant Science
|August 12, 2022
Summary
Plant TGA transcription factors, part of the bZIP family, regulate cellular processes. Their structural characteristics, particularly in N- and C-terminal regions, define functional specificity and DNA-binding properties.
Area of Science:
- Molecular Biology
- Plant Science
- Genetics
Background:
- TGA transcription factors (TGA) are crucial regulators in plants.
- They belong to the basic region leucine zipper (bZIP) family.
- TGAs bind DNA as dimers via a conserved bZIP domain.
Purpose of the Study:
- To summarize plant TGA transcription factors from a structural perspective.
- To correlate structural features with functional roles in transcription regulation.
Main Methods:
- Review of existing literature on TGA structure and function.
- Analysis of sequence variability in TGA proteins.
- Examination of DNA-binding preferences and protein interactions.
Main Results:
- TGA paralogs exhibit distinct DNA-binding preferences despite a shared core sequence.
- N- and C-terminal regions show sequence variability, crucial for functional specificity.
- Structural characteristics influence interactions with other proteins and regulatory elements.
Conclusions:
- Structural insights are key to understanding TGA transcription factor specificity.
- Variations in TGA structure dictate their diverse roles in plant cellular processes.
Keywords:
DOG1 domainTGA transcription factorsfunctional variabilityintrinsically disordered regionsplant transcription regulationpost-translational modificationsstructural characteristicsMore Related Videos
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