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Weighted Gene Coexpression Network Analysis Identifies Crucial Genes Involved in Coronary Atherosclerotic Heart

Jinli Bao1

  • 1Department of Internal Medicine, Municipal Hospital, Zaozhuang, Shandong 277100, China.

Disease Markers
|August 12, 2022
PubMed
Abstract

Insights

This study identifies key genes and pathways involved in coronary atherosclerotic heart disease (CHD) pathogenesis. Findings offer novel biomarkers and therapeutic targets for improving CHD patient outcomes.

Area of Science:

  • Genomics
  • Cardiovascular Research
  • Bioinformatics

Background:

  • Coronary atherosclerotic heart disease (CHD) poses a significant mortality risk with an unclear pathogenic mechanism.
  • There is an urgent need for novel biomarkers and therapeutic strategies for CHD.
  • Understanding CHD pathogenicity is crucial for improving patient outcomes.

Purpose of the Study:

  • To identify crucial gene modules and hub genes associated with coronary atherosclerosis using weighted gene coexpression network analysis (WGCNA).
  • To explore the biological pathways implicated in CHD development.
  • To uncover potential novel biomarkers for CHD.

Main Methods:

  • Weighted gene coexpression network analysis (WGCNA) was performed on the GSE90074 coronary atherosclerosis dataset.
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted.
  • Protein-protein interaction (PPI) network analysis was utilized to identify hub genes.

Main Results:

  • The yellow module was identified as the most critical module associated with CHD.
  • Enriched pathways included inflammatory response, ERK1/2 cascade, lipid catabolism, oxidative stress, apoptosis, and NF-kappa B signaling.
  • Top five hub genes (MMP14, CD28, CaMK4, RGS1, DDAH1) were identified as crucial for CHD development.

Conclusions:

  • The study presents prognostic insights, novel hub genes, and signaling pathways for coronary atherosclerosis treatment.
  • Further investigation into the biological roles of identified genes and pathways is warranted.

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