Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Reply to Reflexing NT-proBNP for sFlt-1/PlGF Ratios That Fall into the Measurement Uncertainty for Preeclampsia Risk Classification.

Clinical chemistry·2026
Same author

Markers in umbilical cord blood in early-onset fetal growth restricted fetuses.

Placenta·2026
Same author

Maternal Exposure to Air Pollution and Fetal Growth: Comparison of Three Exposure Modelling Approaches.

Epidemiology (Cambridge, Mass.)·2026
Same author

Whole genome methylation profiling of menstrual stem cells identifies novel biomarkers for endometriosis.

Communications medicine·2026
Same author

Urinary placental growth factor stability as a critical factor in the reliability of preeclampsia diagnosis.

Biochemia medica·2026
Same author

Impact of prenatal exposure to airborne particulate matter on local functional connections in the cerebral cortex of neonates.

NeuroImage·2026

Related Experiment Video

Updated: Sep 1, 2025

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis
05:30

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

Published on: November 8, 2024

583

First-Trimester Sequential Screening for Preeclampsia Using Angiogenic Factors: Study Protocol for a Prospective,

Cristina Trilla1,2,3, Cristina Luna4, Silvia De León Socorro5

  • 1Obstetrics and Gynecology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Frontiers in Cardiovascular Medicine
|August 12, 2022
PubMed
Summary

This study introduces a new, cost-effective first-trimester screening model for preeclampsia (PE). It aims to identify high-risk pregnancies early for aspirin treatment, reducing maternal and neonatal complications.

Keywords:
first trimestergrowth restrictionpreeclampsiascreeningsequential

More Related Videos

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

13.6K
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

9.8K

Related Experiment Videos

Last Updated: Sep 1, 2025

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis
05:30

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

Published on: November 8, 2024

583
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

13.6K
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

9.8K

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Clinical Diagnostics

Background:

  • Preeclampsia (PE) affects 2-8% of pregnancies, causing significant maternal and neonatal morbidity and mortality.
  • Low-dose aspirin prophylaxis reduces early-onset PE, intrauterine growth restriction (IUGR), and neonatal intensive care unit (ICU) stays.
  • Current universal first-trimester screening using angiogenic markers (PlGF, sFlt-1) is effective but costly.

Purpose of the Study:

  • To evaluate a novel two-step sequential screening model for predicting preeclampsia (PE) in the first trimester.
  • To assess the predictive and preventive capacity of this model in a real-world clinical setting.
  • To determine if this model achieves similar diagnostic performance to universal PlGF testing at a lower economic cost.

Main Methods:

  • Prospective, multicentric, cohort study in a real-world clinical setting.
  • First-trimester risk assessment using a multivariate model (medical history, blood pressure, PAPP-A, UTPI).
  • Sequential screening: PlGF testing only for intermediate-risk patients; aspirin prophylaxis for high-risk individuals.

Main Results:

  • The study hypothesizes that the sequential screening model will have comparable diagnostic performance to universal PlGF testing.
  • The model aims to identify high-risk pregnancies for early intervention with aspirin.
  • Secondary analysis will assess sFlt-1 performance in high and intermediate-risk groups.

Conclusions:

  • The proposed two-step sequential screening model offers a potentially cost-effective approach to early preeclampsia detection.
  • This strategy aims to optimize resource allocation in prenatal care while maintaining high diagnostic accuracy.
  • Early identification and intervention can mitigate the adverse outcomes associated with preeclampsia.