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An intensive, structured, mobile devices-based healthcare intervention to optimize the lipid-lowering therapy

Sonia Ruiz-Bustillo1,2,3,4, Neus Badosa1,2, Ignacio Cabrera-Aguilera1,5,6

  • 1Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Frontiers in Cardiovascular Medicine
|August 12, 2022
PubMed

Insights

An intensive mobile health intervention significantly improved lipid-lowering treatment adherence in acute coronary syndrome patients post-discharge. Over 70% achieved guideline-recommended LDL cholesterol levels, demonstrating effective secondary prevention strategies.

Area of Science:

  • Cardiology
  • Digital Health
  • Preventive Medicine

Background:

  • Lipid-lowering treatment (LLT) is crucial for secondary prevention after acute coronary syndrome (ACS).
  • Current LLT adherence and achievement of guideline-recommended LDL cholesterol (LDLc) levels remain suboptimal.
  • Effective interventions are needed to improve LLT outcomes in high-risk cardiovascular patients.

Purpose of the Study:

  • To evaluate the efficacy of an intensive, mobile device-based healthcare intervention for lipid management post-ACS hospital discharge.
  • To assess the impact of this intervention on achieving target LDLc levels within 12 weeks and at 1-year follow-up.
  • To determine the rate of LLT optimization and associated side effects.

Main Methods:

  • A prospective study (Ambiespective register) involving 497 patients hospitalized for ACS.
  • Implementation of a mobile device-based healthcare intervention including follow-up, lipid monitoring, and LLT optimization.
  • Analysis of LDLc levels at 12 weeks and 1-year post-discharge, with adherence to optimization protocol noted.

Main Results:

  • At 12 weeks, 70.7% of patients achieved LDLc levels ≤ 70 mg/dL.
  • LLT was modified in 38.5% of patients, with a low incidence of side effects (10.7%).
  • At 1-year follow-up, 71.1% of patients with measured LDLc levels met the target of ≤ 70 mg/dL.

Conclusions:

  • An intensive, structured mobile health intervention effectively improves LLT and LDLc control in ACS patients.
  • This approach facilitates achievement of guideline-recommended LDLc levels in over 70% of patients.
  • Mobile health strategies show promise for enhancing secondary cardiovascular prevention and long-term lipid management.
Abstract

Keywords:
cardiovascular risk factorsischemic heart diseaselipid-lowering therapymobile devices-based healthcaresecondary prevention

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